The aim of the present study was to investigate if FCN3 polymorphisms (rs532781899: g. 1637delC, rs28362807: g. 3524_3532insTATTTGGCC and rs4494157: g. 4473C>A) and ficolin-3 serum levels play a role in the susceptibility to leprosy. Here, FCN3 is linked to leprosy.