FASN and cancer: Moreover, these data bolster the premise that tumor-associated FASN is not only necessary to integrate a number of signaling pathways that regulate metabolism, proliferation, and survival in cancer cells, but also has an active role in carcinogenesis by regulating proteins involved in malignant transformation.12, 13, 14 Unraveling the molecular interplay between well-characterized cancer-related networks and FASN-dependent neoplastic lipogenesis is a major challenge that the cancer field is only now beginning to realize.