In this regard, a link between sex steroid receptors and fatty acid metabolism has been established through alterations in FASN expression and malonyl-CoA levels,58, 59, 60 thus making plausible the notion that malonyl-CoA can transmit the metabolic stress imposed by FASN inhibition to ERα activity and E2-responsive gene expression in breast cancer cells. The gene discussed is ESR1; the disease is breast carcinoma.