Here we used CLE to image microscopic blood flow in the hippocampus of KCNA1-null (Kv1.1 knockout (KO)) mice12, 13 (the first of the genetic rodent models to replicate human temporal lobe epilepsy (episodic ataxia type 1))13, and their wild-type (WT) littermates. Here, KCNA1 is linked to hereditary continuous muscle fiber activity.