CCN5 and obesity due to melanocortin 4 receptor deficiency: We here also found that both Chrebpa and Chrebpb were upregulated in the adipose tissue in WISP2 Tg mice and, consistent with this, we found that obesity induced by HFD was associated with lower 13/12- and 5-PAHSA as previously described23 while the levels in the HFD Tg mice were at least as high as in non-obese mice.