In addition, the fact that Nur77 efficiently inhibited cell proliferation in either HepG2 (p53-wildtype) or Hep3B (p53-null) cells (Fig. 1f and Supplementary Fig. 1m), infers that p53 is not required for Nur77 to inhibit HCC. This evidence concerns the gene NR4A1 and hepatocellular carcinoma.