NR4A1 and metabolic dysfunction-associated steatohepatitis: To further confirm this Nur77 inhibitory effect on HCC, we also utilized a streptozotocin (STZ) and high-fat diet (HFD)-induced hepatocarcinogenic mouse model, which mimics the nonalcoholic steatohepatitis (NASH)-hepatocarcinogenic process and closely follows human HCC progression25.