Mitochondrial dysfunction and oxidative stress of repeated exposure to urethane associated with over stimulation of IFN-γ-producing cells, CD11b + Gr-1 + phenotype (Pandey & Gupta, 2012), overexpression of NF-кB, COX-2, STAT3, IL-6 and cyclin D1 resulted in chronic inflammation and lung cancer (Narayan & Kumar, 2012). This evidence concerns the gene ITGAM and lung cancer.