The results of the current study revealed that urethane induced significant increase of LDH activities that indicated by increase in cellular proliferation and cancer promotion.(Liu et al., 2015b) It has been well documented that LDH plays an essential role in development, invasion and metastasis of lung cancer via accumulation of F-fluorodeoxyglucose (F-FDG) through increase in the expression of glucose transporters type 1 (GLUT1) (Zhou et al., 2014). This evidence concerns the gene SLC2A1 and lung cancer.