It is now well established that HIV infection in CD4-negative cells follows some alternate routes for several cell types. Mentioning epithelial cells as target for HIV-1, the mechanism proposed for its transmission through CD4-negative cell involves a specific receptor, i.e. glycosphingolipid galactosylceramide (GalCer) (Delézay et al., 1996; Nittayananta et al., 2016). Here, CD4 is linked to HIV infectious disease.