In the Pmel-1 murine melanoma model, the majority of Pmel-1 CD8 αβ T cells expressing transgenic TCRs specific for the self/tumor specific peptide, gp10025–33 are naive when stimulated in vitro with the gp10025–33 peptide and either IL-2 or IL-15 [44, 83]. This evidence concerns the gene IL15 and neoplasm.