This finding has also been replicated in studies using fine needle aspirates from PC [24, 65].miR-217 acts as a tumor suppressor in PC by targeting KRAS [66] and is involved in epithelial-mesenchymal-transition (EMT) in PC and CP via the miR-217-SIRT1 pathway, which can be triggered by TGF-β1 in inflammatory processes [67]. The gene discussed is SIRT1; the disease is pachyonychia congenita.