It have been shown that mice lacking the gene encoding miR-122a are viable, but they develop hepatosteatosis, NASH and fibrosis and present hepatic infiltration of inflammatory cells that produce pro-tumorigenic cytokine, including IL-6 and TNFα, thus leading to the development of hepatocellular carcinoma [22, 26, 56]. This evidence concerns the gene IL6 and hepatocellular carcinoma.