PTH1R and primary failure of tooth eruption: Non-syndromic PFE is an autosomal dominant disorder that is caused by heterozygous mutations of the Pth1r gene (Frazier-Bowers et al., 2010; Stellzig-Eisenhauer et al., 2010; Yamaguchi et al., 2011; Raberin et al., 2015), leading to protein haploinsufficiency (Roth et al., 2014).