Since the discovery of TRPA1, evidence has suggested that its functional expression on sensory neurones innervating the joints and non-neuronal cells composing the joints such as synoviocytes (Kochukov et al., 2006) and chondrocytes (Nummenmaa et al., 2016) may contribute to RA progression and the associated pain. This evidence concerns the gene TRPA1 and rheumatoid arthritis.