FOS and Parkinson disease: However, there was a decrease of ~40% (P < 0.001, two-way ANOVA) in the density of c-Fos+ nuclei in the 6-OHDA-lesioned striatum of PD-D mice when compared to PD mice (Figure 7B; naïve controls: 20 ± 12; PD mice: non-lesion, 31 ± 10 and 6-OHDA-lesion, 475 ± 55; PD-D mice: non-lesion, 29 ± 12 and 6-OHDA-lesion, 292 ± 49; means ± SEM; n = 10).