Quantitative densitometry analyses of the DL striatum revealed decreases of 41% (P < 0.001, one-way ANOVA) and 45% (P < 0.001, one-way ANOVA) in A2AR-Gαolf PLA signal levels in PD-D mice, when compared to naïve controls and PD mice, respectively (Figure 6F; PD mice, 104 ± 24%; PD-D mice, 59 ± 21%; % of naïve control mice ± SEM; n = 10). Here, ADORA2A is linked to Parkinson disease.