A previous study has shown that excessive ROS induced by exogenous agents is the critical upstream event that leads to DNA damage and apoptosis of cancer cells through multiple signaling pathways [33].Tumor suppressor protein p53 has been identified as one of the downstream signaling protein activated by ROS accumulation on prostate cancer cell induced by a plant flavone, apigenin. The gene discussed is TP53; the disease is prostate carcinoma.