As shown in Figure 7, certain key molecules (ERK1/2, CSF3, FOS, IFNG, and TNF) and significant signaling pathways (the complement system, antigen presentation, macropinocytosis signaling, acute phase response signaling, NF-κB signaling, IL-6 signaling, IL-17 signaling, and p38 MAPK signaling) were associated with an imbalance of cytokines; this imbalance may provide new clues for a better understanding of PS and RA. This evidence concerns the gene NFKB1 and rheumatoid arthritis.