Renalase also protected HK‐2 cells against the cytotoxicity of ioversol and suppressed caspase‐3 activity, oxidative stress and apoptosis induced by H2O2, suggesting that renalase protected CIN in rats through antioxidation, anti‐apoptosis and anti‐inflammation mechanisms 29. The gene discussed is RNLS; the disease is cervical squamous intraepithelial neoplasia.