A renalase‐deficient mouse (renalase KO) model was used to explore the mechanisms mediating renalase's effect on phosphate (PO4‐) excretion and revealed that renalase deficiency is associated with increased renal dopamine (DA) synthesis, stimulated PO4‐excretion and moderately severe hypophosphatemia. This evidence concerns the gene RNLS and hypophosphatemia.