Apart from recent findings that podocyte-specific deletion of Vangl2 leads to increased susceptibility to injury in adult mouse kidney following challenge (Rocque et al., 2014), and links between PCP gene dysfunction and cancer (Elsum et al., 2014; Hatakeyama et al., 2014), the role of the PCP pathway in adulthood is almost entirely unstudied. Here, VANGL2 is linked to cancer.