In some genetic contexts, Col4a1+/Δex41 mice have chronically dysregulated IOPs and optic nerve damage that mimic glaucoma (Gould et al., 2007; Mao et al., 2015b) and COL4A1 mutations can cause developmental glaucoma in patients (Sibon et al., 2007; Deml et al., 2014; Giorgio et al., 2015; Meuwissen et al., 2015; Plancher et al., 2015). This evidence concerns the gene COL4A1 and glaucoma.