COL4A1 and cataract: While cataracts and dilated pupils were seen less frequently in Tie2Cre;Col4a1+/Flex41-neo compared with Col4a1+/Δex41 mice, slit lamp biomicroscopy revealed large and tortuous iris vessels, iridocorneal adhesions and slightly enlarged anterior chambers in the majority of Tie2Cre;Col4a1+/Flex41-neo eyes examined (Fig. S3A,B).