VEGFa and its receptors are in fact expressed in adult brain by neurons and astrocytes (Licht and Keshet, 2013; Mackenzie and Ruhrberg, 2012) and its expression is modulated by pathological conditions (Calzà et al., 2001) in humans (Boer et al., 2008) and in AD (Tarkowski et al., 2004). This evidence concerns the gene VEGFA and Alzheimer disease.