The two most prevalent variants in the human population are NQO1*2 (NQO1 609C>T; NQO1 P187S; allelic frequency: 0.22–0.47) and NQO1*3 (NQO1 465C>T; NQO1 R139W; allelic frequency: 0.00–0.05), which are connected to a higher risk for specific cancers [5–11]. The gene discussed is NQO1; the disease is cancer.