NQO1 and cancer: These findings led to the assumption that the higher cancer risk for the NQO1*3 polymorphism might be caused by erroneous splicing of the pre-mRNA derived from NQO1*3. As a matter of fact, the nucleotide transition found in NQO1*3 disrupts the consensus sequence of the 5′ splicing site required for the correct splicing by the spliceosome and thus rationalizes the observations mentioned above [11].