Deregulation of FASL signaling has been associated with the pathogenesis of several neurodegenerative diseases, including ALS (Aronica et al. 2015; Morello and Cavallaro 2015; Raoul et al. 2006; Aebischer et al. 2013; Petri et al. 2006; Cavallaro and Calissano 2006). Here, FASLG is linked to amyotrophic lateral sclerosis.