EGF and amyotrophic lateral sclerosis: Besides its activity as EGF inhibitor, suramin also contrasts neurotoxicity mediated by nitric oxide synthase (NOS), histone deacetylase (HDAC), and P2Y2 (Xu et al. 2011; Goureau et al. 1993), three proteins that were already extensively implicated in ALS (Janssen et al. 2010; Carlesi et al. 2011).