EGFR and amyotrophic lateral sclerosis: Increased expression of EGFR mRNA observed both in SALS2 patients and SOD1G93A mouse models could thus be related to the reactive astrogliosis surrounding degenerating motor neurons (Figs. 3b and 5) (Vargas and Johnson 2010), and pharmacological inhibition of EGFR signaling cascade may represent a strategy to slow progression of ALS.