CXCR2 and amyotrophic lateral sclerosis: Increased expression of CXCR2 and its rodent homolog (Cxcr2) were found, respectively, in SALS2 patients and SOD1G93A mice at a symptomatic stage (80–100 days of age), suggesting that inflammatory chemokine signaling may exert pathogenic effects both in human and mouse ALS (Figs. 3b and 5).