In humans, ST14 variants may cause autosomal recessive congenital ichthyosis 11 (ARCI11, OMIM #602400), which can be further subclassified into autosomal recessive ichthyosis with hypotrichosis (ARIH) and ichthyosis, follicular atrophoderma, hypotrichosis, and hypohidrosis (IFAH). The gene discussed is ST14; the disease is Ichthyosis-hypotrichosis syndrome.