In contrast overexpression of ALS mutant VAPBP56S increased ER/mitochondria contacts (De Vos et al., 2012), but since in ALS8 patient-derived iPSC neurons VAPB expression is down-regulated because of reduced expression of the VAPBP56S mutant (Mitne-Neto et al., 2011), it is likely that in VAPBP65S-related ALS ER/mitochondria contacts are actually decreased as well. The gene discussed is VAPB; the disease is amyotrophic lateral sclerosis.