MAP6 and amyotrophic lateral sclerosis: Indications that microtubule stability may also be affected in sporadic ALS come from the observation that in post-mortem spinal cord and brain tissue sections of sporadic ALS cases hyperphosphorylated NF-H positive spheroids also show positive staining for microtubule associated protein 6 (MAP6) (Letournel et al., 2003).