Similarly, in stem cell-derived motor neurons from ALS patients bearing three different ALS-causing mutations in TDP-43 (G298S, A315T, M337V), TDP-43-mediated anterograde transport of NEFL mRNA was significantly decreased approximately 10 days after plating and this transport deficit progressively worsened with time in culture (Alami et al., 2014). The gene discussed is NEFL; the disease is amyotrophic lateral sclerosis.