GSK3B and amyotrophic lateral sclerosis: Inhibition of GSK3β was protective in SOD1G93A transgenic mice in some studies (Koh et al., 2007, Feng et al., 2008) but not in others (Gill et al., 2009, Pizzasegola et al., 2009) Moreover, lithium, a known inhibitor of GSK3β, did not show any evidence of benefit on survival in patients with ALS (UKMND-LiCALS et al., 2013).