CDK5 and amyotrophic lateral sclerosis: Transgenic overexpression of p25 in neurons caused MND reminiscent of ALS (Bian et al., 2002) and aberrant activation of Cdk5 has been reported in the spinal cord of mouse models of ALS (Nguyen et al., 2001, Klinman and Holzbaur, 2015, Rao et al., 2016).