Mutations in kinesin-1 or KIF1A have not directly been linked to ALS, but mutations in KIF5A and KIF1A have been identified in hereditary spastic paraplegia (HSP) forms of MND (Fichera et al., 2004, López et al., 2015, Muglia et al., 2014, Citterio et al., 2015, Erlich et al., 2011, Lee et al., 2015a). This evidence concerns the gene KIF5A and hereditary spastic paraplegia.