RHOT1 and amyotrophic lateral sclerosis: Increased cytosolic calcium levels have been reported in cellular models and in motor neurons from transgenic ALS models (Morotz et al., 2012, Siklós et al., 1998) and have been shown to disrupt transport of mitochondria via Miro1 in VAPBP56S-expressing neurons (Morotz et al., 2012).