TARDBP and amyotrophic lateral sclerosis: Similarly, in stem cell-derived motor neurons from ALS patients bearing three different ALS-causing mutations in TDP-43 (G298S, A315T, M337V), TDP-43-mediated anterograde transport of NEFL mRNA was significantly decreased approximately 10 days after plating and this transport deficit progressively worsened with time in culture (Alami et al., 2014).