AR and mild neurocognitive disorder: Finally, dysregulation of transcription in a mouse model of the MND spinal and bulbar muscular atrophy (SBMA) harbouring a pathogenic expanded trinucleotide CAG repeat in the androgen receptor (AR) protein leads to reduced levels of p150Glued mRNA, which is accompanied by impaired retrograde axonal transport (Katsuno et al., 2006).