C9orf72 and amyotrophic lateral sclerosis: Interestingly MAP6 also interacts with TMEM106B, a major risk factor of frontotemporal dementia (FTD) and a modifier of C9orf72-associated ALS and FTD that is involved in axonal transport of lysosomes (Schwenk et al., 2014, van Blitterswijk et al., 2014, Gallagher et al., 2014, Van Deerlin et al., 2010).