VAPB and amyotrophic lateral sclerosis: In addition to decreased ATP production, damage to mitochondria has been associated with the disrupted calcium homeostasis observed in in vitro and in vivo models of mutant SOD1, VAPB, TDP-43, and FUS-related ALS (Carrì et al., 1997, Siklós et al., 1998, Morotz et al., 2012, Stoica et al., 2014, Stoica et al., 2016).