SOX2 and neoplasm: Here we first established an effective concentration range for abrogating clonogenicity in methycellulose, the reduction in the presumptive tumor initiating SP cell fraction (Fig. 11a-b), compared MS-275 with TSA and found MS-275 to be more potent (Fig. 11c-d) while cisplatin (CDDP) was ineffective and reduction in expression of stem cell markers OCT4 and SOX2 by FACs and western blot analysis (Fig. 12a-h).