CDKN1A and glioblastoma: The TSPYL5 gene is of particular interest because, apart from the documented role as a putative TSG in glioblastoma and gastric cancer [7, 14], it has been implicated in cancer signaling pathways involving CDKN1A (p21, WAF1/Cip 1) and pAKT in lung carcinoma cells [15].