Further, individuals with a history of symptomatic infection display a phenotypic skewing of the NK cell repertoire, characterized by a decreased proportion of CD56brightCD16+NKG2A+CD94+NKp46+NKG2D+CD8-NKp30-LILRB1-2B4- NK cells, reflecting WNV-associated shaping of the NK cell repertoire, and suggesting that NK cells could play an important role in WNV pathogenesis in humans. This evidence concerns the gene KLRK1 and infection.