Notably, mutations in NEK1 have been associated with ciliopathy (short-rib thoracic dysplasia 6 with or without polydactyly [SRTD6], homozygous mutation) and amyotrophic lateral sclerosis (ALS, heterozygous mutation) [43, 44], Our data suggests that the non-canonical SLPDL motif corresponds to a distinct site for phosphorylation by AMPK family members as well as 14-3-3 protein binding. This evidence concerns the gene NEK1 and amyotrophic lateral sclerosis.