To investigate the potential regulation of let-7 maturation by LIN28A and LIN28B in NSCLC cells, A549/IR and A549/DDP cells were transfected with two different siRNA (si-LIN28A-1 and si-LIN28A-2, si-LIN28B-1 and si-LIN28B-2) and A549 cells were transfected with expression plasmids (LIN28A plasmid, LIN28B plasmid) (S2 Fig). The gene discussed is LIN28A; the disease is non-small cell lung carcinoma.