To confirm the effect of SFTSV infection on the exogenous IFNα-induced Jak/STAT signaling, Hela cells were infected with SFTSV for 2 hours and cultured for 36hours before IFNα was added to stimulate the cells for 15min, and total proteins were collected for detection of the phosphorylated STAT1.As shown in Fig 3A, TheY701 phosphorylation level of STAT1 was inhibited by SFTSV infection. The gene discussed is IFNA1; the disease is infection.