A recent report indicates that IL-4 production inhibits the induction of intestinal aiTregs in mice carrying an IL-4Rα chain mutation (i.e., inactivation of immunoreceptor tyrosine-based inhibition motif); this mouse model develops food allergic anaphylaxis after sensitization with OVA and the adjuvant staphylococcal enterotoxin B [13]. Here, IL4 is linked to anaphylaxis.