2), IFN-γ production by naïve CD4+ T cells at high concentration of OVA in R23-3 mice (Fig 2 and S2 Fig) may not lead to attenuation of the enteropathy of EW-fed R23-3 mice on day 28, because of the significant decrease of IFN-γ production by MLN CD4+ T cells, but higher responses of IFN-γ by splenic CD4+ T cells may contribute to systemic regulation of inflammatory responses on day 28 of EW diet. The gene discussed is CD4; the disease is Abnormal intestine morphology.