Notably, we demonstrated that TSA can attenuate the EMT process, as evidenced by the increased localized epithelial marker (E-cadherin) and decreased localized mesenchymal marker (α-SMA) in our mouse model of MV-augmented bleomycin-induced pulmonary fibrosis, and that the beneficial effect is mediated through HDAC4-Akt signaling. This evidence concerns the gene CDH1 and pulmonary fibrosis.