FN1 and pulmonary fibrosis: In agreement with our previous findings, we demonstrated that high-VT MV induced and augmented the destruction of the alveolar epithelial barrier and increased capillary permeability, oxidative stress, EMT, profibrotic cytokines regulating ECM remodeling, and excess fibronectin assembly in our VILI and MV-augmented bleomycin-induced pulmonary fibrosis animal models [7, 8, 36].