We have recently shown that the initial rise in tyrosine hydroxylase (TH; the rate limiting enzyme in the catecholamine biosynthesis) gene transcription, phosphorylation of the TH enzyme and induction of protein kinase A (PKA) activity in the adrenal medulla (AM) of normal Sprague-Dawley (SD) rats are similar whether measured during an acute single episode of hypoglycemia or during RH (an animal model of HAAF, [10]). This evidence concerns the gene TH and Hypoglycemia.