A gene set for “Protein folding and response to unfolded proteins” includes molecular chaperons, members of the 70 kDa heat shock protein family (HSP70, HSPA1A, HSPA1B), 40kDa heat shock protein family (DNAJB2), small heat shock proteins (HSP22), heat shock factor 1 (HSF1) and BCL2-associated athanogene 3 (BAG3 –co-chaperone shown to regulate formation of SNARE complex and insulin secretion in beta cells [83]), indicating that activation of UPR may be a significant aspect of the altered responses to hypoglycemia and defective CRR in HAAF. The gene discussed is INS; the disease is Hypoglycemia.