Given that obesity reduces insulin sensitivity [38] and predisposes individuals to abnormal cardio metabolic profiles such as increased waist circumference with increased visceral adiposity and inflammatory adipokines, insulin resistance, elevated triglycerides, decreased high-density lipoprotein cholesterol, and lead to hypertension [39], there is an urgent need for weight management intervention. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.