These findings are in agreement with other clinical AvWS studies: A study by Vincentelli et al. [18] analyzed AvWS in patients with moderate or severe aortic stenosis, and they found a good correlation between vWF:RCo/vWF:Ag with the loss of HMWM only in patients with severe aortic stenosis, while patients with moderate aortic stenosis still had a ratio above 0.7 while loss of HMWM still could be detected via multimer analysis. The gene discussed is RENBP; the disease is aortic stenosis.