Depletion of CD8+ cells caused an increase in tumor size (Fig 3B) and a decrease in immune cell infiltration (Fig 3C), while in contrast depletion of CD4+ T cells reduced growth of both EMT6 and EMT6siCD200 tumors (Fig 4B), along with an increase in CD45+ TILs (Fig 4C) and increased CD8+ cells in DLN (Fig 4D), suggesting that the depleted CD4+ cells may exert an immunosuppressive effect in tumor bearers. The gene discussed is CD8A; the disease is neoplasm.