GLB1 and neoplasm: [3] Therefore, the demonstration of robust senescence induction in intermediate grade tumors is consistent with a role for senescence as a tumor suppressor and may be a putative marker of more favorable tumor outcomes.[27] We did note a wide range in GLB expression in intermediate grade samples after ADT (Fig 2B) suggesting variable tumor responses, and associations between lower GLB1 and increased risk of positive surgical margins were suggested (p = 0.1).