Following senescence induction, a recent study by Dorr and colleagues found that senescent cancer cells uniformly demonstrate increased metabolic activity and elevated levels of proteolytic stress that when combined with glycolysis blocking agents or proteolytic inhibitors resulted in cell lethality.[33] Identifying senescent cells, an objective of GLB1 staining, and targeting these cells for apoptosis in a synthetic lethal approach may be a valid approach in the management of PCa with further study. Here, GLB1 is linked to cancer.