CXCL10 and systemic lupus erythematosus: That being said, it is quite exciting that the two SNPs we identified in the current study are located in the region of IFIH1 known to encode the CARD1/CARD2 domain that drives MDA5-mediated IL-6 and IP-10 production, as well as lying in proximity of a previously identified SNP associated with SLE that also lies within the CARD1/CARD2 domain encoding region of IFIH1 [4].