IFIH1 and systemic lupus erythematosus: We sought to determine if the soluble mediators that significantly associated with mutant Mda5 [2], also associated with the human ortholog, IFIH1. Plasma levels of select soluble mediators and the presence of lupus-associated autoantibody specificities in 357 individuals (SLE patients, FDRs of SLE patients not included in this study, and unrelated, unaffected controls with no family history of SLE were analyzed along with 135 quality controlled SNPs in the region of IFIH1 (Fig 1).