The rat model has also been used to demonstrate that tissue inhibitor of matrix metalloproteinase 1 (TIMP1) secreted from ectopic uterine tissue explants resulted in poorer embryo quality and deleterious effects on ovulation 65 and the authors suggested that novel TIMP‐1‐modulating therapies may be developed to alleviate infertility in women with endometriosis. This evidence concerns the gene TIMP1 and endometriosis.