STAT3 and B-cell chronic lymphocytic leukemia: Because of the myriad of genes that are potentially transcribed by SP132, future work identifying the mechanism(s) controlling SP1 interaction with the promoter region of PRKCB, particularly with respect to how STAT3 may regulate this interaction, will not only be important for understanding how this gene is regulated in the malignant cells of CLL and other diseases where PKCβ is overexpressed, but may also add important insight into the regulation of other genes important to the pathobiology of these diseases.