In addition, it has been reported that mutations in Kelch-like 3 (KLHL3), a member of BTB domain containing Kelch protein, and Cul3 cause hypertension and electrolyte abnormalities36, 37, suggesting that Cul3 and members of KLHL family, such as Keap1 and KLHL3, play important roles in the maintenance of kidney homeostasis. Here, CUL3 is linked to hypertensive disorder.