Consistent with the Nqo1 and Gclc expression, the hyperkeratosis of the oesophagus and forestomach observed in Keap1−/−::Nrf2Flox/Flox mice was rescued in NEKO mice (Fig. 1b–e and Supplementary Fig. 2a–c). This evidence concerns the gene KEAP1 and Hyperkeratosis.