However, IFNB1, TICAM1, STAT1, IRF7, IKBKB, MAVS, TYK2, PIAS4, IL15RA and IFNGR1, which play pivotal roles in antiviral immune signalling, have a single poly(A) site located in their 3′ UTRs and exhibited altered mRNA abundance upon viral infection (Supplementary Tables 3 and 4), suggesting that the de novo transcription regulation of genes without APA may have a greater impact on the participation of these genes in the antiviral response. This evidence concerns the gene MAVS and viral infectious disease.