As shown in Fig. 6e, we found that the expression of most 3′ processing factors was down-regulated upon VSV infection, especially CPSF160, CPSF73, CstF50 and PABPC4. Thus, changes in the expression of 3′ processing factors may be one of the reasons underlying genome-wide APA shortening upon viral infection. The gene discussed is CSTF1; the disease is viral infectious disease.