CCR2 and atherosclerosis: Consistent with their key role in monocyte trafficking and macrophage survival/retention, CCR2/5 have been shown to drive inflammation in a number of animal models of vascular disease, including atherosclerosis 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, and restenosis 52, 53, 54, 55, 56, 57, 58, 59, 60, 61 following revascularization.