A recent study compared the genome‐wide expression profiling between the azoxymethane/dextran sulphate sodium salt‐induced CRC tumour tissues and normal colon mucosa in animals and found that GPC1 expression was significantly upregulated while GPC3 was significantly downregulated in murine colorectal adenocarcinoma as well as in human CRC samples 11. This evidence concerns the gene GPC1 and neoplasm.