In HCT‐116 cells, both AdmiR96 and AdmiR149 virus infection significantly inhibited GPC1 protein expression (Fig. 5A and B, P < 0.001), significantly decreased the percentage of GPC1+ exosomes in the supernatant of cultured HCT‐116 cells (Fig. 5C, P < 0.l001), significantly induced cell apoptosis (Fig. 5D and E, P < 0.001), and significantly decreased the cell proliferation (Fig. 5F) compared to control virus infection. Here, GPC1 is linked to viral infectious disease.