Yip-Schneider et al. also indicated that the combination of the cyclooxygenase 2 inhibitor celecoxib with dimethylaminoparthenolide exhibited significant inhibitory effect of tumor invasion into adjacent organs and metastasis in a carcinogen-induced pancreatic cancer model of Syrian golden hamsters, by decreasing the activity of nuclear factor-kappaB and the expression of prostaglandin E2 and prostaglandin E2 metabolite [39]. Here, PTGS2 is linked to familial pancreatic carcinoma.