Yip-Schneider et al. showed that the combination of nonsteroidal anti-inflammatory drug sulindac with parthenolide inhibited cell growth additively in pancreatic cancer PANC-1 cells and synergistically in pancreatic cancer BxPC-3 and MiaPaCa-2 cells, by increasing the expression level of IkappaBalpha protein and decreasing the binding and transcriptional activities of NF-kappaB DNA [38]. This evidence concerns the gene NFKBIA and familial pancreatic carcinoma.