The combination of TPA and ATRA induced a remarkable decrease ratio of the percentage of mitotic cells to the percentage of caspase-3-positive cells in the tumors compared with tumors from the vehicle-treated control animals. Our laboratory showed that the combination of TPA and diethyldithiocarbamate (DDTC) synergistically inhibited growth and increased apoptosis in human pancreas cancer cells cultured in vitro and pancreas tumor xenografts in nude mice [37]. Here, CASP3 is linked to pancreatic neoplasm.