Huang et al. indicated gum mastic significantly potentiated antiproliferative and apoptotic effects of gemcitabine in both pancreatic cancer BxPC-3 and COLO 357 cells by increasing the expression of IkappaBalpha and Bax protein, blocking NF-kappaB activation and downregulating the expression of Bcl-2 protein [28]. This evidence concerns the gene BAX and familial pancreatic carcinoma.