Rimmon et al. indicated that the combination of escin with gemcitabine showed only additive effect in pancreatic cancer PANC-1 cells, while escin combined with cisplatin led to a significant synergistic cytotoxic effect in PANC-1 cells by downregulating NF-κB signaling pathway [27]. Here, NFKB1 is linked to familial pancreatic carcinoma.