VEGFA and acute myeloid leukemia: First, the constitutive mediator release by primary AML cells shows a wide variation for each individual mediator, and this patient heterogeneity was maintained in cocultures as we observed significant correlations between the levels for AML cells cultured alone and the corresponding coculture for 22 of the 23 cytokines (Kendall’s tau correlation analysis), VEGF being the only exception.