Altogether, these results suggest a biphasic response of γδ T lymphocytes during CMV infection: (i) an early phase mobilizing IFNγ-producing and cytotoxic γδ T cells, which act together with other immune effectors (particularly NK cells) for rapid and efficient viral control and (ii) the generation of EM γδ T cells able to protect the host in the long-term and whose effector and memory functions are under consideration in our laboratory. Here, IFNG is linked to cytomegalovirus infection.