In AP GPA, we observed a strong decrease of IL-12/IL-23p40 production by cDCs in response to TLR3-L (***p < 0.001) and more modestly to TLR4-L (**p < 0.01) and TLR7/8-L (**p < 0.01) as compared to HC, whereas no difference was detected for RP GPA. The gene discussed is TLR7; the disease is granulomatosis with polyangiitis.