Low production of IL-12/IL-23p40 was observed in pDCs from HC that was further decreased in AP-MPA patients in response to TLR7/8 ligand (*p < 0.05) and in AP-GPA after TLR9 stimulation (**p < 0.01) (Figure 3C). The gene discussed is TLR7; the disease is microscopic polyangiitis.