Although genetic polymorphisms of the gene (CHRNA7) encoding the α7 nACh receptor subunit are known to be involved in various epileptic disorders in humans, including idiopathic generalized epilepsy, childhood absence epilepsy, juvenile myoclonic epilepsy and benign epilepsy of childhood with centrotemporal spikes (Elmslie et al., 1997; Helbig et al., 2009; Endris et al., 2010; Liao et al., 2011), functional role and mechanisms of α7 nACh receptors in modulating seizure generation and/or epileptogenesis are still unknown. Here, CHRNA7 is linked to idiopathic generalized epilepsy.