Analysis of our vesicle populations for collagen type I (Lee et al., 1995) and platelet-derived growth factor receptor beta (PDGFRβ) (Borkham-Kamphorst et al., 2004; Thoen et al., 2011), showed an enhanced expression in the patient populations with early liver fibrosis, as compared to the healthy controls. This evidence concerns the gene PDGFRB and Hepatic fibrosis.