ProNGF, the precursor of mature Nerve Growth Factor (NGF), is the most abundant NGF form in the brain and increases markedly in the cortex in Alzheimer's Disease (AD), relative to mature NGF (Francke et al., 1983; Scott et al., 1983; Fahnestock et al., 2001; Peng et al., 2004). Here, NGF is linked to early-onset autosomal dominant Alzheimer disease.